約翰是一個事業逐漸走下坡的山路腳踏車選手,沮喪的他回到加州的故鄉,沒想到惡夢卻就此展開!他成為連續謀殺案的嫌疑犯,因為小鎮上出現可疑的滑行痕跡。事實上真正的兇手是一條超級巨蟒,它的鱗片比盔甲還堅硬,視力範圍是一般蛇的 9 倍,最駭人的是有如無底洞的胃。這是由遺傳學家魯道夫博士研究出的基因變種生物,目的是要破壞美國中部遊擊隊的武器。而此計畫後來卻被 CIA 搶走而被迫終止,魯道夫博士為了報復而將巨蟒放生到小鎮上進行試驗,然而巨蟒卻立即變成連博士自己也無法控制的吃人魔。約翰為了洗刷冤屈必須與巨蟒對抗,他是否能成功擊敗這個恐怖的怪物,或是成為另一塊俎上肉?
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Sheriff Griffin Wade: Let me see if I got this straight. You boys--what department did you say you were from again? Dootsen: NSA. Sheriff Griffin Wade: Okay. So you got this... Bart Parker: An operative. Sheriff Griffin Wade: Yeah, an operative. This real Rambo type. Dootsen: This guy makes Rambo look like Richard Simmons. Sheriff Griffin Wade: Uh-huh, and you've had this man locked up in a cage since 1974? Bart Parker: In a metal box. Sheriff Griffin Wade: In a metal box in a military psychiatric unit. And somehow he escaped, and he's the one that done all these murders? Bart Parker: That's about the size of it. Any questions? Sheriff Griffin Wade: Just one. Do you expect me to believe this load of horseshit? Bart Parker: Let me put it this way, Sheriff. It would be highly expedient if you would believe this horseshit.
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